Advanced Life Support References

Abuelazm MT, Ghanem A, Katamesh BE, et al. Defibrillation strategies for refractory ventricular fibrillation out-of-hospital cardiac arrest: a systematic review and network meta-analysis. Ann Noninvasive Electrocardiol. 2023;28(5):e13075. doi:10.1111/anec.13075

Aicua Rapun I, Novy J, Solari D, Oddo M, Rossetti AO. Early Lance-Adams syndrome after cardiac arrest: prevalence, time to return to awareness, and outcome in a large cohort. Resuscitation. 2017;115:169-172. doi:10.1016/j.resuscitation.2017.03.020

Akhtar W, Baston VR, Berman M, et al. British societies guideline on the management of emergencies in implantable left ventricular assist device recipients in transplant centres. Intensive Care Med. 2024;50(4):493-501. doi:10.1007/s00134-024-07382-y

Ali JM, Abu-Omar Y. Complications associated with mechanical circulatory support. Ann Transl Med. 2020;8(13):835. doi:10.21037/atm.2020.03.152

Aljanoubi M, Almazrua M, Drennan I, et al. Emergency front of neck airway access in adult cardiac arrest. Consensus on Science with Treatment Recommendations. International Liaison Committee on Resuscitation (ILCOR) Advanced Life Support Task Force. Updated December 5, 2023. Accessed September 28, 2024. https://costr.ilcor.org/document/emergency-front-of-neck-airway-access-in-adult-cardiac-arrest-als-tf-scr 

Aljanoubi M, Almazrua AA, Johnson S, et al. Emergency front-of-neck access in cardiac arrest: a scoping review. Resusc Plus. 2024;18:100653. doi:10.1016/j.resplu.2024.100653

Alqahtani S, Nehme Z, Williams B, Bernard S, Smith K. Long-term trends in the epidemiology of out-of-hospital cardiac arrest precipitated by suspected drug overdose. Resuscitation. 2019;144:17-24. doi:10.1016/j.resuscitation.2019.08.036

Alshahrani MS, Aldandan HW. Use of sodium bicarbonate in out-of-hospital cardiac arrest: a systematic review and meta-analysis. Int J Emerg Med. 2021;14(1):21. doi:10.1186/s12245-021-00344-x

Alsumait A, El Fawal N, Abouzaki N. Appropriateness of sodium bicarbonate use during resuscitation if in-hospital cardiac arrest at a tertiary care center [Abstract]. J Am Coll Cardiol. 2022;79(9):1653.

Ameloot K, De Deyne C, Eertmans W, et al. Early goal-directed haemodynamic optimization of cerebral oxygenation in comatose survivors after cardiac arrest: the neuroprotect post-cardiac arrest trial. Eur Heart J. 2019;40(22):1804-14. doi:10.1093/eurheartj/ehz120

American Red Cross Scientific Advisory Council, Adult Resuscitation Subcommittee. Cardiac arrest secondary to hyperthermia. Updated June 2022. Accessed October 1, 2022. https://arc-phss.my.salesforce.com/sfc/p/#d0000000bxKz/a/3o000000xbcO/fiXlBOC4yOUzzlKF0UMLbDBi_zMbRVZgJG6NYqOrpOE

American Red Cross Scientific Advisory Council, Adult Resuscitation Subcommittee. Double sequential external defibrillation for refractory shockable rhythm. June 2023. Accessed September 7, 2025. https://arc-phss.my.salesforce.com/sfc/p/#d0000000bxKz/a/KV000000G0Yp/wJkL09dkIUnO9yz1mL2QRTeGh9CH7hyfgHthq0Z8Ndo

American Red Cross Scientific Advisory Council, Adult Resuscitation Subcommittee. Targeted temperature management. August 2021. Accessed October 23, 2024. https://arc-phss.my.salesforce.com/sfc/p/#d0000000bxKz/a/3o000001Ropl/inwj2VYqjbiuLM9LI48XcSZp_Z75J9Sfj8VDMxWlAmE

American Red Cross Scientific Advisory Council, Adult Resuscitation Subcommittee. Traumatic brain injury osmotic agents. Updated June 2022. Accessed October 1, 2022. https://arc-phss.my.salesforce.com/sfc/p/#d0000000bxKz/a/3o000000xQot/suacrg0bfRsd3sV5B22bkNAwB7MtQTrTGNw6jMIJ254 

American Red Cross Scientific Advisory Council, Adult Resuscitation Subcommittee. Vasopressin and steroids for in-hospital cardiac arrest. January 2022. Accessed September 7, 2025. https://arc-phss.my.salesforce.com/sfc/p/#d0000000bxKz/a/3o000000tbUr/OVFRCCLF2i78jilyIgFOlMgjWEi0IiDolsvy.ftscnc

Anantharaman V, Ng BL, Ang SH, et al. Prompt use of mechanical cardiopulmonary resuscitation in out-of-hospital cardiac arrest: the MECCA study report. Singapore Med J. Jul 2017;58(7):424-431. doi:10.11622/smedj.2017071

Andersen LW, Isbye D, Kjærgaard J, et al. Effect of vasopressin and methylprednisolone vs placebo on return of spontaneous circulation in patients with in-hospital cardiac arrest: a randomized clinical trial. JAMA. 2021;326(16):1586-1594. doi:10.1001/jama.2021.16628

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Baloglu Kaya F, Acar N, Ozakin E, Canakci ME, Kuas C, Bilgin M. Comparison of manual and mechanical chest compression techniques using cerebral oximetry in witnessed cardiac arrests at the emergency department: a prospective, randomized clinical study. Am J Emerg Med. 2021;41:163-169. doi:10.1016/j.ajem.2020.06.031

Barcala-Furelos R, Fernández-Méndez M, Cano-Noguera F, Otero-Agra M, Morán-Navarro R, Martínez-Isasi S. Measuring the physiological impact of extreme heat on lifeguards during cardiopulmonary resuscitation: randomized simulation study. Am J Emerg Med. 2020;38(10):2019-2027. doi:10.1016/j.ajem.2020.06.042

Barssoum K, Patel H, Rai D, et al. Outcomes of cardiac arrest and cardiopulmonary resuscitation in patients with left ventricular assist device; an insight from a national inpatient sample. Heart Lung Circ. 2022;31(2):246-254. doi:10.1016/j.hlc.2021.05.096

Belohlavek J, Smalcova J, Rob D, et al. Effect of intra-arrest transport, extracorporeal cardiopulmonary resuscitation, and immediate invasive assessment and treatment on functional neurologic outcome in refractory out-of-hospital cardiac arrest: a randomized clinical trial. JAMA. 2022;327(8):737-747. doi:10.1001/jama.2022.1025

Berg KM, Bray JE, Ng KC, et al. 2023 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations: summary from the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces. Circulation. 2023;148(24):e187-e280. doi:10.1161/cir.0000000000001179.

Berg KM, Hsu CH, Considine J, et al. Cardiopulmonary resuscitation and defibrillation for cardiac arrest when patients are in the prone position. Consensus on Science with Treatment Recommendations. International Liaison Committee on Resuscitation (ILCOR). Updated April 19, 2021. Accessed August 15, 2021. https://costr.ilcor.org/document/prone-cpr-als-systematic-review

Berg KM, Soar J, Andersen LW, et al. Adult advanced life support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Circulation. 2020;142(16 Suppl 1):S92-S139. doi:10.1161/cir.0000000000000893

Bernard SA, Bray JE, Smith K, et al. Effect of lower vs higher oxygen saturation targets on survival to hospital discharge among patients resuscitated after out-of-hospital cardiac arrest: the EXACT randomized clinical trial. JAMA. 2022;328(18):1818-1826. doi:10.1001/jama.2022.17701

Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346(8):557-563. doi:10.1056/NEJMoa003289

Bierens J, Barcala-Furelos R, Beerman S, et al. Airway management in drowning. Consensus on Science with Treatment Recommendations. International Liaison Committee on Resuscitation (ILCOR) Basic Life Support Task Force. Updated April 19, 2021. Accessed August 15, 2021. https://costr.ilcor.org/document/bls-856-airway-management-in-drowning-tf-scoping-review

Bierens J, Barcala-Furelos R, Beerman S, et al. Criteria for discharge in drowning. Consensus on Science with Treatment Recommendations. International Liaison Committee on Resuscitation (ILCOR). Updated April 19, 2021. Accessed August 15, 2021. https://costr.ilcor.org/document/bls-856-criteria-for-discharge-in-drowning-tf-scoping-review

Bierens J, Barcala-Furelos R, Beerman S, et al. Extra corporeal membrane xygenator (ECMO) in drowning. Consensus on Science with Treatment Recommendations. International Liaison Committee on Resuscitation (ILCOR) Basic Life Support Task Force. Updated April 19, 2021. Accessed August 15, 2021. https://costr.ilcor.org/document/bls-856-extra-corporeal-membrane-oxygenator-ecmo-in-drowning-tf-scoping-review

Bierens J, Barcala-Furelos R, Beerman S, et al. Mechanical ventilation in drowning. Consensus on Science with Treatment Recommendations. International Liaison Committee on Resuscitation (ILCOR) Basic Life Support Task Force. Updated April 19, 2021. Accessed August 15, 2021. https://costr.ilcor.org/document/bls-856-mechanical-ventilation-in-drowning-tf-scoping-review

Boone MD, Oren-Grinberg A, Robinson TM, Chen CC, Kasper EM. Mannitol or hypertonic saline in the setting of traumatic brain injury: what have we learned? Surg Neurol Int. 2015;6:177. doi:10.4103/2152-7806.170248

Bougouin W, Slimani K, Renaudier M, et al. Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock. Intensive Care Med. 2022;48(3):300-310. doi:10.1007/s00134-021-06608-7

Brain Resuscitation Clinical Trial Group. Randomized clinical study of thiopental loading in comatose survivors of cardiac arrest. N Engl J Med. 1986;314(7):397-403. doi:10.1056/nejm198602133140701

Bray JE, Hein C, Smith K, et al. Oxygen titration after resuscitation from out-of-hospital cardiac arrest: a multi-centre, randomised controlled pilot study (the EXACT pilot trial). Resuscitation. 2018;128:211-215. doi:10.1016/j.resuscitation.2018.04.019

Bray J, Skrifvars MB, Bernard S. Oxygen targets after cardiac arrest: a narrative review. Resuscitation. 2023;189:109899. doi:10.1016/j.resuscitation.2023.109899

Bray JE, Smyth MA, Perkins GD, et al; Basic Life Support Task Force Collaborators. Basic Life Support: 2025 International Liaison Committee on Resuscitation Consensus on Science With Treatment Recommendations. Circulation. 2025 Oct 21;152(16_suppl_1):S34-S71. doi: 10.1161/CIR.0000000000001364. Epub 2025 Oct 22. PMID: 41122845.

Bro-Jeppesen J, Annborn M, Hassager C, et al. Hemodynamics and vasopressor support during targeted temperature management at 33°C versus 36°C after out-of-hospital cardiac arrest: a post hoc study of the target temperature management trial. Crit Care Med. 2015;43(2):318-327. doi:10.1097/ccm.0000000000000691

Burke CR, Chan T, Brogan TV, et al. Extracorporeal life support for victims of drowning. Resuscitation. 2016;104:19-23. doi:10.1016/j.resuscitation.2016.04.005

Callaway CW. Epinephrine for cardiac arrest. Curr Opin Cardiol. 2013;28(1):36-42. doi:10.1097/HCO.0b013e32835b0979

Callaway CW, Soar J, Aibiki M, et al. Part 4: Advanced life support: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Circulation. 2015;132(16 Suppl 1):S84-S145. doi:10.1161/cir.0000000000000273

Cashen K, Sutton RM, Reeder RW, et al. Calcium use during paediatric in-hospital cardiac arrest is associated with worse outcomes. Resuscitation. 2023;185:109673. doi:10.1016/j.resuscitation.2022.109673

Cecconi M, Hernandez G, Dunser M, et al. Fluid administration for acute circulatory dysfunction using basic monitoring: narrative review and expert panel recommendations from an ESICM task force. Intensive Care Med. 2019;45(1):21-32. doi:10.1007/s00134-018-5415-2

Chamberlain MJ. Emergency treatment of hyperkalaemia. Lancet. 1964;1(7331):464-467. doi:10.1016/s0140-6736(64)90797-4

Champigneulle B, Bellenfant-Zegdi F, Follin A, et al. Extracorporeal life support (ECLS) for refractory cardiac arrest after drowning: an 11-year experience. Resuscitation. 2015;88:126-131. doi:10.1016/j.resuscitation.2014.11.023

Celebi Yamanoglu NG, Yamanoglu A. The effect of calcium gluconate in the treatment of hyperkalemia. Turk J Emerg Med. 2022;22(2):75-82. doi:10.4103/2452-2473.342812

Chen H, Song Z, Dennis JA. Hypertonic saline versus other intracranial pressure-lowering agents for people with acute traumatic brain injury. Cochrane Database Syst Rev. 2020;1(1):Cd010904. doi:10.1002/14651858.CD010904.pub3

Cheskes S, Dorian P, Feldman M, et al. Double sequential external defibrillation for refractory ventricular fibrillation: the DOSE VF pilot randomized controlled trial. Resuscitation. 2020;150:178-184. doi:10.1016/j.resuscitation.2020.02.010

Cheskes S, Verbeek PR, Drennan IR, et al. Defibrillation strategies for refractory ventricular fibrillation. N Engl J Med. 2022;387(21):1947-1956. doi:10.1056/NEJMoa2207304

Choi HJ, Noh H. Successful defibrillation using double sequence defibrillation: case reports. Medicine (Baltimore). 2021;100(10):e24992. doi:10.1097/md.0000000000024992

Contenti J, Corraze H, Lemoël F, Levraut J. Effectiveness of arterial, venous, and capillary blood lactate as a sepsis triage tool in ED patients. Am J Emerg Med. 2015;33(2):167-172. doi:10.1016/j.ajem.2014.11.003

Couper K, Andersen LW, Drennan IR, et al. Intraosseous and intravenous vascular access during adult cardiac arrest: a systematic review and meta-analysis. Resuscitation. 2025;207:110481. doi:10.1016/j.resuscitation.2024.110481

Couper K, Andersen LW, Drennan IR, et al. Intravenous and intraosseous drug administration for cardiac arrest in adults. Consensus on Science with Treatment Recommendations. International Liaison Committee on Resuscitation (ILCOR) Advanced Life Support Task Force. Updated November 6, 2024. Accessed August 2, 2025. https://costr.ilcor.org/document/io-v-iv-drugs-als-2046-tf-sr

Couper K, Ji C, Deakin CD, et al. A randomized trial of drug route in out-of-hospital cardiac arrest. N Engl J Med. 2025;392(4):336-348. doi:10.1056/NEJMoa2407780

Couper K, Quinn T, Booth K, et al. Mechanical versus manual chest compressions in the treatment of in-hospital cardiac arrest patients in a non-shockable rhythm: a multi-centre feasibility randomised controlled trial (COMPRESS-RCT). Resuscitation. 2021;158:228-235. doi:10.1016/j.resuscitation.2020.09.033

Crescioli E, Lass Klitgaard T, Perner A, Lilleholt Schjørring O, Steen Rasmussen B. Lower versus higher oxygenation targets in hypoxaemic ICU patients after cardiac arrest. Resuscitation. 2023;188:109838. doi:10.1016/j.resuscitation.2023.109838

Cronberg T, Skrifvars MB, Nolan JP, et al. Post-cardiac arrest seizure prophylaxis and treatment. Consensus on Science with Treatment Recommendations. International Liaison Committee on Resuscitation (ILCOR). Updated January 5, 2020. Accessed September 28, 2024. https://costr.ilcor.org/document/post-cardiac-arrest-seizure-prophylaxis-and-treatment-tf-systematic-review

Dabrowski W, Siwicka-Gieroba D, Robba C, et al. Potentially detrimental effects of hyperosmolality in patients treated for traumatic brain injury. J Clin Med. 2021;10(18). doi:10.3390/jcm10184141

Dankiewicz J, Cronberg T, Lilja G, et al. Hypothermia versus normothermia after out-of-hospital cardiac arrest. N Engl J Med. 2021;384(24):2283-2294. doi:10.1056/NEJMoa2100591

Deakin CD, Morley P, Soar J, Drennan IR. Double (dual) sequential defibrillation for refractory ventricular fibrillation cardiac arrest: a systematic review. Resuscitation. 2020;155:24-31. doi:10.1016/j.resuscitation.2020.06.008

Desch S, Freund A, Akin I, et al. Angiography after out-of-hospital cardiac arrest without ST-segment elevation. N Engl J Med. 2021;385(27):2544-2553. doi:10.1056/NEJMoa2101909

Dezfulian C, Orkin AM, Maron BA, et al. Opioid-associated out-of-hospital cardiac arrest: distinctive clinical features and implications for health care and public responses: a scientific statement from the American Heart Association. Circulation. 2021;143(16):e836-e870. doi:10.1161/cir.0000000000000958

Dillon DG, Montoy JCC, Nishijima DK, et al. Naloxone and patient outcomes in out-of-hospital cardiac arrests in California. JAMA Netw Open. 2024;7(8):e2429154. doi:10.1001/jamanetworkopen.2024.29154

Doan TN, Adams L, Schultz BV, et al. Insights into the epidemiology of cardiopulmonary resuscitation-induced consciousness in out-of-hospital cardiac arrest. Emerg Med Australas. 2020;32(5):769-776. doi:10.1111/1742-6723.13505

Dohi S, Ichizuka K, Matsuoka R, Seo K, Nagatsuka M, Sekizawa A. Coronary perfusion pressure and compression quality in maternal cardiopulmonary resuscitation in supine and left-lateral tilt positions: a prospective, crossover study using mannequins and swine models. Eur J Obstet Gynecol Reprod Biol. 2017;216:98-103. doi:10.1016/j.ejogrb.2017.07.019

Drennan IR, Berg KM, Böttiger BW, et al; Advanced Life Support Task Force Collaborators. Advanced Life Support: 2025 International Liaison Committee on Resuscitation Consensus on Science With Treatment Recommendations. Circulation. 2025 Oct 21;152(16_suppl_1):S72-S115. doi: 10.1161/CIR.0000000000001360. Epub 2025 Oct 22. PMID: 41122842.

Drennan IR, Dorian P, McLeod S, et al. Double sequential external defibrillation for refractory ventricular fibrillation (DOSE VF): study protocol for a randomized controlled trial. Trials. 2020;21(1):977. doi:10.1186/s13063-020-04904-z

Drennan IR, Nikolaou N, Netherton S, et al. Early coronary angiography post-ROSC. Consensus on Science with Treatment Recommendations. International Liaison Committee on Resuscitation (ILCOR) Advanced Life Support Task Force. Updated April 19, 2021. Accessed August 15, 2021. https://costr.ilcor.org/document/early-coronary-angiography-post-rosc-als-costr-systematic-review

Eastwood G, Nichol AD, Hodgson C, et al. Mild hypercapnia or normocapnia after out-of-hospital cardiac arrest. N Engl J Med. 2023;389(1):45-57. doi:10.1056/NEJMoa2214552

Eastwood GM, Schneider AG, Suzuki S, et al. Targeted therapeutic mild hypercapnia after cardiac arrest: a phase II multi-centre randomised controlled trial (the CCC trial). Resuscitation. 2016;104:83-90. doi:10.1016/j.resuscitation.2016.03.023

Eastwood GM, Tanaka A, Espinoza ED, et al. Conservative oxygen therapy in mechanically ventilated patients following cardiac arrest: a retrospective nested cohort study. Resuscitation. 2016;101:108-114. doi:10.1016/j.resuscitation.2015.11.026

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Extracorporeal Life Support Organization. ELSO Live Registry Dashboard of ECMO Patient Data. ELSO. Accessed October 23, 2023. https://elso.org/registry/elsoliveregistrydashboard.aspx

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Granfeldt A, Holmberg MJ, Nolan JP, Soar J, Andersen LW. Targeted temperature management in adult cardiac arrest: systematic review and meta-analysis. Resuscitation. 2021;167:160-172. doi:10.1016/j.resuscitation.2021.08.040

Granfeldt A, Holmberg MJ, Soar J, et al. Temperature control in adult cardiac arrest. Consensus on Science with Treatment Recommendations. International Liaison Committee on Resuscitation (ILCOR). Updated January 2024. Accessed September 28, 2024. https://costr.ilcor.org/document/temperature-control-in-adult-cardiac-arrest-als-tf-sr

Greif R, Bray JE, Djärv T, et al. 2024 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations: summary from the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces. Circulation. 2024;150(24):e580-e687. doi:10.1161/cir.0000000000001288

Griffiths MJD, McAuley DF, Perkins GD, et al. Guidelines on the management of acute respiratory distress syndrome. BMJ Open Respir Res. 2019;6(1):e000420. doi:10.1136/bmjresp-2019-000420

Grunau B, O’Neil B, Giustini D, Drennan IA, Lavonas EJ. Opioid-specific advanced life support therapies for cardiac arrest. Consensus on Science with Treatment Recommendations. International Liaison Committee on Resuscitation (ILCOR) Advanced Life Support Task Force. Accessed August 2, 2025. https://costr.ilcor.org/document/opioid-specific-advanced-life-support-therapies-for-cardiac-arrest-als-3451-tf-sr

Grunau B, O’Neil BJ, Giustini D, Drennan IR, Lavonas EJ. Opioid-associated cardiac arrest: a systematic review of intra-arrest naloxone and other opioid-specific advanced life-support therapies. Resusc Plus. 2025;22:100906. doi:10.1016/j.resplu.2025.100906

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Haywood KL, Ji C, Quinn T, et al. Long term outcomes of participants in the PARAMEDIC2 randomised trial of adrenaline in out-of-hospital cardiac arrest. Resuscitation. 2021;160:84-93. doi:10.1016/j.resuscitation.2021.01.019

Henry TD, Tomey MI, Tamis-Holland JE, et al. Invasive management of acute myocardial infarction complicated by cardiogenic shock: a scientific statement from the American Heart Association. Circulation. 2021;143(15):e815-e829. doi:10.1161/cir.0000000000000959

Hernández G, Ospina-Tascón GA, Damiani LP, et al. Effect of a resuscitation strategy targeting peripheral perfusion status vs serum lactate levels on 28-day mortality among patients with septic shock: the ANDROMEDA-SHOCK randomized clinical trial. JAMA. 2019;321(7):654-664. doi:10.1001/jama.2019.0071

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Hirsch K, Sandroni C, Skrifvars M, Humaloja J. EEG for prediction of good neurologic outcome. Consensus on Science with Treatment Recommendations. International Liaison Committee on Resuscitation (ILCOR) Advanced Life Support Task Force. Updated December 15, 2022. Accessed October 4, 2023. https://costr.ilcor.org/document/eeg-for-prediction-of-good-neurological-outcome-als-tfsr

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Holmberg MJ, Berg KM, Ikeyama T. Oxygenation and ventilation targets in adults with return of spontaneous circulation after cardiac arrest. Consensus on Science with Treatment Recommendations. International Liaison Committee on Resuscitation (ILCOR) Advanced Life Support and Basic Life Support Task Forces. Accessed August 2, 2025. https://costr.ilcor.org/document/oxygen-and-carbon-dioxide-targets-in-patients-with-return-of-spontaneous-circulation-after-cardiac-arrest-als-3305-3506-3516-3517-tf-sr

Holmberg MJ, Fernando S, Elshaer A, Leong C, Drennan I. Vasopressors in adult cardiac arrest. Consensus on Science with Treatment Recommendations. International Liaison Committee on Resuscitation (ILCOR) Advanced Life Support Task Force. Accessed August 2, 2025. https://costr.ilcor.org/document/vasopressors-in-adult-cardiac-arrest-als-3208-tf-sr

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